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Many factors can contribute to GERD, including obesity, diet, and certain medications

Chronic hypoxia drives the conversion of Tregs to pro-inflammatory Th17 cells via the HIF-1 pathway, characterized by reduced CD25 expression, increased OX40 expression, and exhaustion of immunosuppressive function, which exacerbates Th1/Th17 cell polarization and the release of pro-inflammatory factors such as IL-17A and IFN- (Lantz et al., 2024)

How Semaglutide Works: Three Mechanisms Semaglutide mimics GLP-1, a naturally occurring incretin hormone released by the small intestine after you eat

Common side effects of semaglutide diminish over time

[DOI] [PubMed] [Google Scholar] 78.Fazzino T.L., Dorling J.L., Apolzan J.W., Martin C.K