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Mirena is a reliable and versatile hormonal IUD that offers both contraception and treatment for certain medical conditions

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Furthermore, the reduction in adipose tissue mass likely reduced obesity-associated systemic inflammation by reducing the release of pro-inflammatory adipokines, which can drive cartilage degeneration [80] and abnormal subchondral bone remodelling [81]

It does not affect gut hormones or slow gastric emptying, and it does not stimulate the central nervous system the way phentermine does