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Perturbed NAD + metabolism in response to infection Microbial infection, including viruses and bacteria, causes an imbalance in the cellular redox environment, thus inducing different responses, e.g., antioxidant defenses, cell signaling, immune response and other processes

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Extrahepatic malignancies - particularly colorectal, breast, and pancreatic cancer - are more common in MASLD patients independent of metabolic syndrome components [3-5]