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Reported anecdotal side effects from non-clinical use have been minimal, typically limited to mild injection site reactions

In the Billon 2023 paper, a single 25 mg/kg intraperitoneal dose in mice was enough to induce an acute aerobic exercise transcriptional signature in muscle within hours

DOI: 10.1038/s41467-017-01114-1 Formulation strategies for therapeutic peptide stability pH, ionic strength, co-solvency

Namely, we should consider egr-1 gene both positive and negative association

This fear leads to a rigid adherence to a one-size-fits-all protocol, even when it is not clinically appropriate for the individual