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In addition to SOD-mimetic compounds, Salen-based organic compounds, possessing hydrogen peroxide scavenging activity have been prepared and tested as Glutathione peroxidase mimetics

Furthermore, the potential of traditional-medicine-derived active compounds, repurposed drugs, and de-novo synthetic small molecules to induce dual death should be thoroughly explored

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Safety in Context: Study Limitations While the clinical trial safety data for AOD-9604 is extensive and reassuring, understanding the limitations of this evidence base is essential for balanced interpretation