Mitochondrial dysfunction, including systemic deficiency of the electron transport chain complex I, is a well-established player in the pathogenesis of both sporadic and familial PD [96,97,98]
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However, FDA prescribing information recommends considering discontinuation for sustained significant increases in resting heart rate, and patients with persistent palpitations or heart rate above 100 bpm should consult their healthcare provider
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Many people continue aiming for protein at each meal (and often a snack) because it supports fullness and helps maintain muscle while portions are smaller