This multi-layered approach allowed the efficient prioritization of three candidates from large chemical libraries, supporting its applicability as a general framework for early-stage GLP-1R ligand discovery
Krogh-MadsenRPlomgaardPMllerKMittendorferBPedersenB
For example, SGTL2i can increase uric acid excretion through co-inhibition of glucose and uric acid reabsorption (77), reducing uric acid levels which have been independently associated with cardiovascular and renal events (77)
We also found that the FXR-antagonistic BAs, including TMCA, HDCA or UDCA, antagonized the effect of CDCA, a potent FXR agonist, on the Shp mRNA expression and GLP-1 secretion in NCI-H716 cells (Fig
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