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Elastase treatment promoted cellcell fusion mediated by RaTG13 and Khosta-2 S proteins, whereas trypsin and thermolysin did not (Fig

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While the channels are mostly similar to those seen in immune cells, there are important differences

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This is possible through brain signals, hormones, the immune system, and the gastrointestinal microbiota

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Moreover, cyclooxygenase inhibitors, which suppress prostaglandin E2 synthesis, have been shown to reduce fungal biofilm formation, highlighting their potential as adjunctive agents in antifungal therapy ( 4.4 Antifungal drugs targeting metabolic pathways and enzymes Fungal metabolism involves a wide array of biochemical pathways essential for growth, survival, and virulence, including N-acetylglucosamine utilization, trehalose metabolism, lipid biosynthesis, energy production, and intracellular transport (Pan et al., 2018

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The protective mechanism of methionine is likely due to its conversion to sulfur-containing amino acids, including cysteine, which are depleted by the renal excretion of sulfated acetaminophen metabolites (50)

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