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Studies 2 have found that ghrelin increases cravings in alcohol-dependent heavy drinkers and that antagonizing this peptide reduces the motivation to consume alcohol, leading to an overall decreased alcohol intake

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13 Two meta-analyses of other GLP-1 RA CVOTs found that GLP-1 RAs were associated with greater rates of DR progression, but both studies found that the effect was driven by the extent of hemoglobin A1c reduction, rather than the medications themselves