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In the body, IGF-1 can activate growth a multitude of bodily tissues, including the nerves, bone, kidneys, and liver

Caution is also advised in patients with conditions such as asthma, cardiac disease, renal impairment, migraine, or epilepsy, as HCG can lead to fluid retention that may worsen these conditions

Neurologic, cognitive, hematologic, or mucosal features can point to a shortfall, as can risk factors such as malabsorption, autoimmune gastritis, relevant medications, or nitrous oxide exposure

Pernicious anaemia, an autoimmune loss of intrinsic factor, is the classic one