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Glutathione undergoes a reaction with the toxic substances, facilitated by enzymes such as glutathione S-transferases, to form a conjugate known as a glutathione adduct, which is then further metabolized in the liver to form mercapturic acid, a water-soluble compound that can be easily excreted through the urine

Also, there is lack of literature evaluating its efficacy.[] IV administered GSH is not directly utilized by cells but is cleaved into its component amino acids and is resynthesized to GSH intracellularly after transmembrane transport

Tirzepatide, being approved, additionally carries a labeled boxed warning for thyroid C-cell tumors based on rodent studies

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