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A significant portion of the population, especially in low- and middle-income nations, cannot afford these expenses because they are frequently included in the ultimate cost of the medications

Lincoff et al

Furthermore, evidence from research and clinical use of the drug class has led to the initiation of clinical trials with GLP1 RAs in other prominent agingrelated diseases, including chronic kidney disease (CKD) and Alzheimer's disease

In these recent studies, the potential risk of hospitalization for HF was significantly increased only in patients taking saxagliptin

Instead, we took advantage of three amino acid substitutions (E505Q, T527M, and K573P