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New England Journal of Medicine (2025) The REDEFINE 1 Phase 3 trial was a landmark 68-week, double-blind, randomized study comparing CagriSema (cagrilintide 2.4 mg plus semaglutide 2.4 mg) with semaglutide alone, cagrilintide alone, and placebo in 3,417 adults with obesity or overweight without diabetes

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in the Journal of Clinical Endocrinology and Metabolism (2006) demonstrated that combined GHRH and GHS administration produces GH release that exceeds the sum of either agent alone a true synergistic effect