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PMID: 25612929

IGF-1 plays a central role in tumor development by stimulating proliferation and inhibiting apoptosis in cancer cells. Pollak, Nature Reviews Cancer Acromegaly-Like Symptoms (Rare) In extremely high or prolonged dosesespecially when stacked with HGHIGF-1 may contribute to: Bone thickening (jaw, forehead, hands) Enlarged soft tissue Headaches or carpal tunnel symptoms These side effects mimic acromegaly , a condition caused by excessive GH/IGF-1 signaling

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KPV has been studied in cell and animal models related to intestinal inflammation, but it should not be viewed as a proven treatment for Crohns disease, ulcerative colitis, or other inflammatory bowel diseases

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