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Additionally, growing awareness of early diagnosis, preventive care, and lifestyle modification programs are being actively promoted by public health groups and health authorities is indirectly increasing demand for GLP-1based therapies

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Nevertheless, ADA 2023 suggests that metformin's benefits on MACE remain potential and dubious [9], indicating that for patients with high risk of MACE, metformin combined with SGLT-2i or GLP-1 RAs with proven cardiovascular benefits may still contribute to the decrease of MACE risk