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After anesthetization by intraperitoneal injection of 10% chloral hydrate (v/w), the mice were fixed on a stereotactic instrument and stereotactically injected with KA (250 ng/l) into the hippocampus

Ficlatuzumab (AV-299) is a humanized monoclonal anti-HGF IgG1 antibody that enchains to HGF, thereby inhibiting the HGF/c-Met interplay

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