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74 , 48894897 (2008) Sakoulas, G

Chronic hypoxia promotes ceramide hydrolytic metabolism by activating the HIF-2/Acer2 signaling pathway, and thereby downregulates PP2A activity The above study found that hypoxia caused -syn hyperphosphorylation by inhibiting PP2A activity

Patients commonly experience gastrointestinal side effects including nausea, vomiting, diarrhea, and constipation, which may further compromise nutritional status