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Interventions aimed at blocking collagen and hyaluronan production, such as a neutralizing antibody against TGF- [127], the angiotensin inhibitor losartan [128,129,130,131], or the antifibrotic drugs tranilast and pirfenidone [132,133,134] have shown promising results in alleviating solid stress and increasing breast tumor blood supply and drug delivery

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The team then administered orforglipron or another small-molecule drug, danuglipron, and identified brain regions where they induced activity