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Saponins mostly prevent gastric ulcer formation through an anti-secretory mechanism which inhibits excessive gastric juice secretion along with the total acid output, which leads to a pH value alteration in the gastrointestinal tract [54]

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26 This A1A2 continuum underscores the functional plasticity of astrocytic responses and highlights that reactive astrocytes are not uniformly detrimental, but rather contextdependent modulators of neuroinflammatory signalling

In older patients it is usually a form of deliberate self-harm