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Headaches may result from dehydration due to reduced fluid intake or gastrointestinal side effects, changes in eating patterns including meal skipping or caffeine withdrawal, blood glucose fluctuations, or individual susceptibility factors

Acknowledgements We thank the laboratory members of Y.T

Depletion of SAMe and methionine can have significant consequences for health, disrupting the methylation pathway and leading to various health issues

PMID: 27692757, PMCID: PMC5459385, DOI: 10.1016/j.amepre.2016.08.013

Examples include allergies to a commercial inactive ingredient, a dose strength not available in pen form, or a different injection route