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[38] [163] Amphetamine addiction is largely mediated through increased activation of dopamine receptors and co-localized NMDA receptors [note 14] in the nucleus accumbens

I reviewed the trials and the epidemiology in detail here

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Roupret M, Hupertan V, Yates DR, Catto JW, Rehman I, Meuth M, Ricci S, Lacave R, Cancel-Tassin G, de la Taille A, Rozet F, Cathelineau X, Vallancien G, Hamdy FC, Cussenot O (2007) Molecular detection of localized prostate cancer using quantitative methylation-specific PCR on urinary cells obtained following prostate massage