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If neurological symptoms are present, treatment may involve 1mg injections on alternate days until no further improvement is seen, followed by maintenance therapy

(6) Chi Zhang, Yun Xie, Haicheng Chen, Linyan Lv, et al (2020) FOXO4-DRI alleviates age-related testosterone secretion insufficiency by targeting senescent Leydig cells in aged mice Aging (Albany NY)

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Patients with Lebers hereditary optic neuropathy should not receive B12 due to the risk of optic nerve damage