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For semaglutide, HbA1c is measured at baseline and every 3 months until stable

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ester solvents such as methyl acetate, ethyl acetate (EtOAc), n-propyl acetate, isopropyl acetate, n-butyl acetate, the base used in the present invention can be selected from but not limited to inorganic bases selected from alkali metal carbonates such as sodium carbonate, potassium carbonate, lithium carbonate, cesium carbonate and the like