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Retatrutide produced clinically meaningful reductions in HbA1c across the dose range alongside body-weight loss of about 17% at the top dose, with a safety profile in line with GLP-1 and dual GIP/GLP-1 agonists [2]

EBioMedicine 74(103739):103739 Gupta NA, Mells J, Dunham RM, Grakoui A, Handy J, Saxena NK, Anania FA (2010) Glucagon-like peptide-1 receptor is present on human hepatocytes and has a direct role in decreasing hepatic steatosis in vitro by modulating elements of the insulin signaling pathway

It is not suitable for type 1 diabetes or diabetic ketoacidosis, and is not recommended in severe gastrointestinal disease

VAS, visual analogue scale

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