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This is likely due to it being endogenously synthesized all throughout the body and it is basically found in all cells, sometimes in rather high concentrations
Nutrient selection in the absence of taste receptor signaling
Buse, T
It initiates a cascade of deleterious changes, including impaired energy metabolism, enhanced ROS production, and intracellular calcium overload
Importantly, the weight-reducing efficacy appears comparable to that observed in common, polygenic obesity, as preliminarily evidenced by subgroup analyses from large trials such as SURMOUNT-1
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