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When you lose 10 pounds of muscle because your GLP-1 stripped it away and you didn't do anything to stop it, your resting metabolism drops by roughly 60 to 70 calories per day

Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted by L-cells in the distal small intestine and colon in response to nutrient ingestion

"Across five positive Phase 3 studies, retatrutide has shown powerful efficacy, and we believe it could be an important future tool in the management of cardiometabolic health," said Kenneth Custer, Ph.D., executive vice president and president, Lilly Cardiometabolic Health

GLP-1s: What They Do (and Dont Do) How they work: GLP-1 receptor agonists mimic a gut hormone that slows gastric emptying, increases satiety, and regulates blood sugar