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The Cholesterol Treatment Trialists Collaboration analyzed individual data from 19 double-blind randomized trials 123,940 people, followed for a median of 4.5 years

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5.5 Conclusion and future direction Recognizing the limitations of conventional delivery routes in targeting the CNS, IN administration provides a non-invasive alternative that not only bypasses the BBB but also avoids hepatic first-pass metabolism

DECLARE-TIMI 58: participants baseline characteristics

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