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For long-term use spanning more than one year, 12 weeks on followed by 8 weeks off is the advised structure to minimize cumulative receptor desensitization
Similarly, SkQ1, another mitochondria-targeted antioxidant, exhibits potent free radical-scavenging capacity and acts directly within mitochondria to protect cells from ferroptosis-induced damage (69)
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A delayed pharmacological treatment strategy attenuates noise-induced tinnitus in rats