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We know their history, manage their other conditions, and can adjust the weight-loss plan in context not in a vacuum

7 Indications for both classes of drugs may vary, owing to different modes and mechanisms of action in T2D

Diabetes Care 20(4):537544 Ramachandran A, Snehalatha C, Mary S et al (2009) Pioglitazone does not enhance the effectiveness of lifestyle modification in preventing conversion of impaired glucose tolerance to diabetes in Asian Indians: results of the Indian Diabetes Prevention Programme-2 (IDPP-2)

However, self-help cognitive behavioral therapy programs have become increasingly available and may be similarly effective

The incidence of depression or anxiety decreased with increasing duration of treatment after the initiation of GLP1-RA medication (Table 5)