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79 While the direct renoprotective mechanisms of GLP-1RAs are still under investigation, their ability to enhance natriuresis and suppress pathogenic angiotensin II production presents a valuable therapeutic strategy in HFpEF complicated by CKD

This side effect is often dose-dependent and may be more pronounced when starting treatment or increasing the dosage

And 5-amino-1mq is the compound that researchers have developed specifically to shut it down