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First disclosed by Eli Lilly investigators in 2018 under the development code LY3298176, tirzepatide marked a deliberate departure from decades of incretin research that had focused almost exclusively on GLP-1 mono-agonism

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The authors found that a significant amount of the administered drug was distributed outside the nose as the experiment progressed and they concluded superior drug retention behavior for the ISG formulation than for the solution sample, suggesting the potential of reducing the drug dose when intranasal administration was applied