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Hematology, 23(9), 653657

Advanced Drug Delivery Reviews , 97 , 4155

ROS damage the mitochondria of dermal papilla cells, disrupt the ECM, accelerate collagen degradation, and impair the DNA repair mechanisms that keep follicular stem cells healthy and functionally active

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Although targeting macropinocytosis could be a key strategy for overcoming resistance to glutamine uptake blockade, further studies are necessary to examine whether macropinocytosis can overcome tumor cell resistance to glutamine antimetabolites or GLS inhibitors that target enzymes involved directly in glutamine metabolism