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Although much of the current research focuses on the mechanisms of gut microbiota adaptation to high-altitude environments and the pathogenesis of chronic high-altitude diseases across various species, the strong association between the onset and progression of acute high-altitude illness and gut microbiota dysbiosis should not be overlooked

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Notably, T helper 1 (Th1) cells, natural killer (NK) cells, and CTLs release interferon-gamma (IFN-), a pro-inflammatory cytokine that is crucial to vitiligo pathogenesis and CTL-mediated melanocyte death in depigmented areas