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both endogenous (ROS) and exogenous (mercury and persistent organic pollutants)

American Society for Metabolic and Bariatric Surgery 2020 estimate of metabolic and bariatric procedures performed in the United States

Creatinine levels may decline alongside reductions in muscle mass, which can complicate kidney marker interpretation over time

According to the UK SmPC, the most common side effects include: Nausea (very common, affecting more than 1 in 10 people): Usually most pronounced during the first few weeks of treatment and often diminishes with continued use Diarrhoea (common, affecting up to 1 in 10 people): Typically mild to moderate in severity Vomiting (common): More frequent at higher doses Constipation (common): May occur alongside other gastrointestinal effects Abdominal pain or discomfort (common): Relatively frequent during treatment initiation Decreased appetite (very common): An expected effect related to the medication's action Dyspepsia/indigestion (common): May contribute to discomfort after eating Beyond gastrointestinal effects, other recognised adverse reactions include injection site reactions (redness, itching, or swelling at the subcutaneous injection site), fatigue , and dizziness

PubMed Central, Femminella, Grazia Daniela, et al