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Valine flux analysis in vivo verified the inhibition of BCATm but also demonstrated that this strategy is unable to lower distal BCAA catabolites and disease biomarkers, likely due to influx of metabolic substrates distal to the BCATm block

subsequent purification revealed the active species as a Gly-His-Lys tripeptide complexed with copper

However, its important to manage expectations around the timeline for these results

Novo Nordisk developed CagriSema as the successor to their blockbuster semaglutide therapy, recognizing that even 2.4 mg of standalone semaglutide left room for improvement