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10.1111/jcmm.13333 24 KillgoreJ.SmidtC.DuichL.Romero-ChapmanN.TinkerD.ReiserK.et al (1989)

50 Simtuzumab (GS-6624) is a humanized monoclonal antibody directed against lysyl oxidase-like molecule 2 (LOXL2)

Upregulation of Sirt induced deacetylation of downstream FOXO genes and inhibition of NAD+ synthesis caused downregulation of the Sirt3/FOXO4 pathway, which was consistent with inhibited TCA cycle and ATP synthesis, thus affecting the survival of mice [32]

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