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For example, Tirzepatides association with reduced cataract incidence versus Naltrexone/Bupropion (HR 0.46, 95% CI: 0.230.92, p = 0.025) demonstrates both statistical significance and substantial effect size, with the confidence interval excluding unity while encompassing clinically meaningful reductions

Tirzepatide has been shown to reduce blood pressure in clinical trials

Other notable side effects include injection site reactions (redness, itching, or swelling at the injection site), fatigue, and hypoglycemia, particularly when tirzepatide is used in combination with insulin or sulfonylureas