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Table 3 describes supplements for which there is relevant literature in ME/CFS

Targeting Sleep with Single-Ingredient Supplements Once foundational needs are considered, Huberman advises looking at single-ingredient supplements for specific goals like sleep enhancement, rather than multi-ingredient blends (which are better suited for foundational support)

The autophagy adaptor p62/SQSTM1, essential for targeting ubiquitinated substrates to autophagosomes, is mutated in ALS and FTD, where impaired p62 function results in aggregation-prone protein accumulation and neuronal toxicity

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In human studies, GLP-1 RA therapy has been associated with changes in microbial diversity and enrichment of specific taxa