Cost per day: $0.03-0.04 Annual cost: $10-15 Best value if: Budget is tight and you have no genetic issues Methylcobalamin: $15-25 per 120 capsules (1,000mcg) Cost per day: $0.13-0.20 Annual cost: $50-75 Best value if: You want optimal absorption and neurological support Hydroxocobalamin (injection): $15-30 per vial (1,000mcg) Monthly cost: $15-30 (one injection/month maintenance) Annual cost: $180-360 Best value if: You have malabsorption or pernicious anemia (no point paying for oral that wont absorb) Adenosylcobalamin: $25-40 per 60 capsules (1,000mcg) Cost per day: $0.40-0.65 Annual cost: $150-240 Best value if: You need mitochondrial/energy support beyond what methylcobalamin provides Combination formulas: $20-40 per 60 capsules (500mcg each of 2-3 forms) Cost per day: $0.35-0.65 Annual cost: $130-240 Best value if: You want comprehensive coverage and dont mind the premium The value calculation: Cyanocobalamin to Methylcobalamin = 5x price increase for better absorption/activity Methylcobalamin to Injections = 3-4x price increase for 100% absorption Is it worth it
Al-Zaidy SA, Sahenk Z, Rodino-Klapac LR, Kaspar B, Mendell JR
By inhibiting the NNMT enzyme, it prevents the consumption of nicotinamide, allowing it to be recycled back into NAD+ more efficiently
The Indian Journal of Medical Research
The typical use case is with: knee, hip, shoulder, rotator cuff, and low back issues (source)
