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The researchers measured the womens bone mineral density and other aspects of bone before and after the two-year intervention

In addition to PDHC and OGDH(L)C, this action of thiamine is mediated by two other ThDP-dependent multienzyme complexes, i.e., those of branched chain 2-oxo acid dehydrogenase (BCODH) and OADH, functioning in the pathways of degradation of branched-chain -amino acids, and lysine and tryptophan, respectively (Figure 1)

It can be found that GB and DAA have similarities in the pathways related to the regulation of ferroptosis, both of which may mobilize downstream genes by influencing Nrf2 activity, and finally exert the role of anti-ferroptosis, while achieving a balance of iron metabolism and lipid peroxidation

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Curr Med Chem 8(7):851862