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When cagrilintide is paired with semaglutide as CagriSema, the gap narrows23% for CagriSema versus 25.5% for Zepbound in a direct head-to-head trialbut Zepbound still holds a modest edge

It works by acting on the central nervous system to suppress appetite and increase feelings of satiety

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Diabetes 59(Suppl 1):611-P, Abstract Thomas C, Gioiello A, Noriega L et al (2009) TGR5-mediated bile acid sensing controls glucose homeostasis

Glucagon-like peptide-1 modulates neuronal activity in the rat's hippocampus