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Eligibility is restricted to adults with a BMI of at least 35 kg/m and at least one weight-related comorbidity, or a BMI of 40 or above, who have not achieved meaningful weight loss through nutritional management, and who are under specialist supervision with a lifestyle programme

Glucagon-like peptide-1 receptor (GLP-1R) agonists have emerged as therapeutic agents for obesity in adults and have shown benefits outside of weight loss