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Am J Physiol Regul Integr Comp Physiol 2016;310:R88595.ArticlePubMedPMC 41

Additionally, GPX3 can interact with GSH and thioredoxin reductase, or with thioredoxin alone, to produce electrons for GSH in the presence of GSH depletion (18), which in turn protects the cells from ROS-induced deoxyribonucleic acid (DNA) and cellular damage (15)

In eukaryotes, the use of alternative initiation codons deciphers whether the produced GSSG reductase will be cytosolic or mitochondrial [12]