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The first incretin-based drug approved specifically for weight loss was liraglutide (Saxenda), developed by Novo Nordisk
A more recent population-based longitudinal cohort study that assessed GGT variability (a calculated index assessing the coefficient of variation, standard deviation, and variability independent of the mean) in 119,201 individuals found that higher GGT variability was strongly associated with a significant increase in the incidence of hospitalized heart failure, particularly among dyslipidemic subjects [65]
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Canonical Wnt signaling works downstream of iron overload to prevent ferroptosis from damaging osteoblast differentiation
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