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It effectively separates complete succinylcarnitine and methylmalonylcarnitine from their isomers, allowing for more accurate quantification of these metabolites and aiding in distinguishing typical methylmalonic acidemia from succinyl-CoA synthetase-related defects

5A and B) as well as the major breakdown product of glutaminolysis, aspartate (Fig

The core protective effects of citrulline are largely exerted through its metabolite NO, which operates via three interrelated mechanisms: first, by inhibiting the mitochondrial translocation of the fission protein Drp1, thereby preserving mitochondrial structural integrity

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