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Characteristics that influence the ability of peptides to cross the BBB include: Size: The BBB selectively allows molecules of a certain size to pass through, typically only permitting small molecules

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These medications have seen an explosion in sales with the approval and off-label use for weight loss, typically resulting in a reduction in body weight of 15-21% when combined with nutrition and exercise

doi: 10.1016/S0140-6736(17)30069-7 92 Pi-SunyerXAstrupAFujiokaKGreenwayFHalpernAKrempfMet al