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Most people experience side effects About 80 percent of adults taking tirzepatide or semiglutide, the active ingredients in the most commonly prescribed GLP-1s, experienced at least one side effect, according to a 2024 review study published in the journal Obesity Pillars

[DOI] [PMC free article] [PubMed] 76.Karp NA, Meehan TF, Morgan H, Mason JC, Blake A, Kurbatova N, et al

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Available findings suggest that the initial dosage of allopurinol should be low, particularly in patients with renal impairment

However, results can vary from person to person, and it is crucial to consult with a healthcare professional before beginning any new supplement regimen