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Comparison: Tirzepatide vs Other GLP-1 Agonists and Palpitation Risk Key Takeaways Tirzepatide heart palpitations occur in 25% of patients and are caused by vagal tone modulation, fluid volume reduction, and electrolyte shifts

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In this study, we developed a PBPK model of tirzepatide using both in vitro and in vivo data, and verified the model in adults, then scaled it to children and adolescents with both normal and obese body weights

In a clinical trial with pediatric patients aged 10 years and older [see Clinical Studies (14.2)], anti-liraglutide antibodies were detected in 1 (2%) liraglutide injection-treated patient at week 26 and 5 (9%) liraglutide injection-treated patients at week 53

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