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This triple receptor agonism distinguishes it from currently approved medicines such as semaglutide (GLP-1R only) and tirzepatide (GLP-1R and GIPR)

Within this multifaceted pathological landscape, the GLP-1 system has emerged as a cornerstone of modern metabolic pharmacology, transcending its initial role as a simple glycemia-regulating incretin (Kong et al., 2026

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Many patients undergoing surgery have diabetes, prediabetes, or unrecognized diabetes

These botanicals have been traditionally used for digestive health and have shown promise in supporting healthy weight management through various metabolic pathways