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With the effects seen of the GLP-1 family of drugs on preventing kidney damage in diabetes, liver disease (non-alcoholic or metabolic-associated steatosis, NASH/MASH), and addiction, this drug class is exceeding all expectations

The bottom line: Our findings suggest that GLP-1RA and SGLT2i (and especially SGLT2i with the lowest number needed to treat (NNT) for nearly all study outcomes) may be the preferred glucose-lowering agents for cardiovascular risk reduction in patients at moderate risk for CVD, building on and consistent with existing RCT evidence in the high-risk population. This report highlights potential preference for GLP-1 drugs as a first-line treatment for Type 2 diabetes related to its cardioprotective effect

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